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"ó" " " " " " " " " " "í" " " " " " # " " " " " " #³ " " " " #" " " " " " " " " " #" # #"!E" " " " " " " " " "é" " #" " " " " " " " " # " " " " " " " " " #" " # " " " " " " " "ó" " " # " " " " " " #" " " " " " " "!F ÄÎÑÒÈÆÅÍÈß ÔÓÍÄÀÌÅÍÒÀËÜÍÎÉ, ÊËÈÍÈ ÅÑÊÎÉ ÌÅÄÈÖÈÍÛ È ÔÀÐÌÀÖÈÈ Ìàòåðèàëû 67-îé íàó íîé ñåññèè ñîòðóäíèêîâ óíèâåðñèòåòà 2-3 ôåâðàëÿ 2012 ãîäà ÂÈÒÅÁÑÊ 2012

#" " 6 1 6 + 6 1 5. 1 + 3 7 8 " " " 5#³ 4 3 1-5 2. 8 2# 4 3 1 " 7 0 flfi : " # # # #fl#»#»# #, #fi# # # # # # #fl#fi# # # # #»# # # # # # # ".". " #fl# # # # # fl» fl flfi : #fi# # #fl# #, # # # #fi# #fi# # # #fl#fi# # # # #»# # # # # # # ".". " # # # # # flfi» fl : " # # # #fl#»#»# # ".#³. " #fl# # #, #fi.#.#. "é.". " # # # #, # # # # #fl#»#»# # ".". "é# # # # # # #, # # # # #fl#»#»# # ".". "í# # # # #, # # # # #fl#»#»# # ".". " # # # # # #»# # #, # # # # #fl#»#»# # ".#. " # # #fl# # # # # #, #fi.#.#. "í.". " # # # #fl# # #`, # # # # #fl#»#»# # "."é. " # #fi, #fi.#.#. "."ó. " #fl# # # #, # # # # #fl#»#»# # "ó.". " # # # # # #»# # #, # # # # #fl#»#»# # ".". " # # # # # # #, # # # # #fl#»#»# # ".". " # #fi# # # # #, # # # # #fl#»#»# # "ó."é. " # #`#fl#, # # # # #fl#»#»# # "."ó. " #fl# #fl# # #, # # # # #fl#»#»# # ".". # # # # # # # #, #fi# # #fl# # #.". " # #fl# #»#fl#fl# # #, #fi# # #fl# # ".". " # #«# # # # #, #fi# # #fl# # ".". " # # # # # # # #, #fi# # #fl# # ".". " # # # #, #fi# # #fl# # ".". " # #»# # # # # #, #fi# # #fl# # ".". ## # # # # #. " 7 0 " # #»# # # #fl# # # # # # #fi# # #fl# # # # # # # #, # # # # # #`#fl#»# # # # #fl#fi# # # # # # # # # # # # # #. "ó# # #fl# # # # # 6 7 -# # # # #`# # # #»#fl#»#»# # #»# # # # #fi# # # # # # # # # #fl# #»# # #fl# #. " # # #fl#«#»# : " "é"ó#, 2 0 1 2. 5 2 1 #». I S B N 9 7 8-9 8 5-4 6 6-5 1 8-4 " # #fl#fi#»# # # # #fl# # # #fl # # #fl# #fl# # # # # #fl# # # #»#«# # # # # #fl # # # #fl# # # # # # # #»# # #ˆ#fl# # # # # #«# #fl - # # # #«# # # # # # #, # #fl#fi# # # # #, # # # # # # # #, # # # # # # # # # # # # #fi# # # # # # # # # #fl# # #, # # # # # #fl # # # # # #»# # #»# # # # # # # # -# # # # # # # # # # # # # # # #, # # # # #`#fl#»# # # # # # # # # # # # # # #»# #fl# # # # # #. " # # #á#`#fl# # #»# # # # # # #fl#fi# #ˆ# # # # # # # #fi# # # #`#fl# # # " "é"ó# # #»# #fl# # # # # #»# # # # # # # # # #`#fl#»# # # # # #fi# # # # # # # # # #fl# # #. #" " 6 1 6 + 6 1 5. 1 + 3 7 8 " " " 5#³ 4 3 1 + 5 2. 8 2# 4 3 1 I S B N 9 7 8-9 8 5-4 6 6-5 1 8-4 #" «" # # #fl#«#»# # # # # #»# #fi# # #»# # #fl# # # # # #fl#fi# # # # #»# # # # # # # #fl# #»# # #fl#», 2 0 1 2

# # # # # # # # # # # # # # # # # # #»# # " "ó" # # # # #»# # # # # # # # # # # # #`#fl#»# # # # # #fi# # # # #fl# #fl# # # # # # # # #`#fl# # # # # # # # #fl# # # # # # # # #«# # # #fl# # # # # # # # # # #fl# # # # # # # ( R = 0, 5 8 6, # < 0, 0 0 0 1, n = 3 9 ) ; 2 ) # # # # # #á # # # # #fl# # # # #á # #fl# #fi# # # # # # #fl# #«#fl# # - # # # # # # # # # # # # # # # # # # #»# # " "ó" # # # # # # # # # # # # #`#fl# # # # # # # #fl# # # # #«#fl# # -# # # # # # # # # # # # # #«# # # # # # # # #fl# #fl# # # # #fl# # # # #»# # # # # # # 4 -# # # # # # # #fl# # # # # #«# # # # #«# # #fl# #fl - 1 )" #fl#»# -#»# #»# #fl# # «" # # " # # # # #» # # # #fl# # #»# #fl# # # # #»# # # # # # # # # # #»# #fi# # # # #`#fl#»# # #fl# # # # # # # # # #`#fl#»# # #fl# # # # # # # ( R = 0, 3 8 1, # = 0, 0 1 7, n = 3 9 ) ; 3 ) # # # # # #á # # # # #fl# # # # #á # # #fl# # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # " "ó" ; #»# #fl#fi# #fl# #»# # # # #fl# #fi# # # # # # #fl# #«#fl# # -# # # # # # # # # # # 2 )#fi# 9 7, 6 % # # # #«# # # # # # # # #«# # #fi# #fl# #»# #«#»# # #fl# # # # # # # # # # # #»# # " "ó" # # # # # # # # # # # # #`#fl# # # # # # # #fl# # # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # #á, # # # # #`# # # # # # # # # ; # # # # #«# # # # # # #, # #fl # # # # #»# #ˆ# # #»# # # # # #»#»# #«#fl# # -# # # # # - 3 ) " # # # # #»# # # # # # # #fl# # #«#fl# # -# # # # # # # # # # # # # - # # # ( R = 0, 5 3 3, # < 0, 0 0 0 1, n = 3 9 ) ; 4 ) # # # # # #á # # # # #fl# # # # #á # # # # # #»# # " "ó" # # # #fl#`# #fl# #»# # # # # # #fl# # # # #» #»# #«# # # # - #»# #fl#fi# #fl# #»# # # # #fl# #fi# # # # # # #fl# #«#fl# # -# # # # # # # # # # # # # # # # -# # # #fi# # # # # # # # # # # # # # # # # # # # # #, # # # #«# # #fl#fl # # # # # # # # #»# # " "ó" # # #«#ˆ# # # # # # #`#fl#»# # # # # # # # #«# # # # # # #, # # # # # #fl# # # # #«#fl# # # #«# # #fl# # # # # # " " ; # # # #fi# # # # # # # # # # # # #`#fl# # # # # # # # #fl# # # # # # # #fi#fl # # # # #«# # # #fl# # # # # # # # #«# # # # # # # # # # #»# # # # # #«# # # #fl# # # # # # # # # # #fl# # # # # # # # # # #fl# # # # # ( R = 0, 5 2 2, # = 0, 0 0 1, n = 3 9 ). #»# #fl#fi# # #fl # # # # # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # # # # # " # # #fl# #fl# #fl#`# #»# #fl# # # #fl # # # # #fl# # # # # # # # # # # # #á # # # #`# # # # #fl # # # # # #`# #á# #»# ; # # # # # # # #á# # # #»# # # # # # # # # #fl# # # # # # # # # # # #«#fl# # -# # # # # - 4 )" #fl# # -# # # # # # # # # # # # # # # # # # #»# # " "ó" #«# # #fl#fl # # # # # # # # # # # # # #»# # " "ó" #«# # # # # # #» #«# # # #fl# # # # # # # # # # #fl# # # # # # # # # #»# #»# # # #fl# # # # # # # #fl# # # # # # #»# # #á # # # # # - #fi# # # # # # # # #«# # # # # # # # # # #«# # # #fl# # # # # # # # # #fl# # # # #, #«# # # # # #á#ˆ#fl# #»# # # # #»# # # # # # # # # # # #«#fl# # -# # # # # # # # # # # # # #«# # # # # # # # #fl# # # # # # # # #. " # #`# #»# #fl# # #fl # # # # # #fl# # # # # #»# # # ( r i s k r a t i o ) # # - # # # # # #, #`# # # # # # #»# # #fl# # # # # # #»# # # # (#«# # #fl#fl 2 0 % ) #«#fl# # - # # # # # # # # # # # # # # # # # # #»# # " "ó" #»# # # # #fl# #»# # # #fl# # # # #«# # - b e t a - l a c t a m s b y b e t a - l a c t a m a s e s / T.% S a w a i / / N i p p o n # # # #fl# # # # # #fi# # #fl# # # # ( 1, 9 4-3, 2 4 ) # #fl# # # # # # #»# # # #fl# #»# #fl# # R i n s h o. 1 9 9 7. V o l. 5 5, #ª 5. P. 1 2 2 5-1 2 3 0. # # # # #«# # # #fl# # # # # # # # # #fl# # # # # # # # # # # # # #fl# # # # # # # #, 2. N a t i o n a l C o m m i t t e e f o r C l i n i c a l L a b o r a t o r y S t a n - #`# # # # # # # # #fl# #»# # #«# # #fl#fl # # #»# # # # #`# #»# # # #fl # # # #fl# # d a r d s. P e r f o r m a n c e s t a n d a r d s f o r a n t i m i c r o b i a l s u s c e p t i - # #fl# # # # # #`# # # # # # # # # # #`#fl# # # # #»# #fl# # # #fl#`#fl# # #, #«# # #fl#fl b i l i t y t e s t i n g ; 1 0 t h i n f o r m a t i o n a l s u p p l e m e n t / / N C C L S #`# #»# # # # # # # # #`#fl# # # # # # # #«# # # # # # # # #fl# #fl# # #, # # # #á#`# # D o c u m e n t M 1 0 0 - S 9. 1 9 9 9. P.% 1 4 1-1 5 6. #»# # # # # #fi#fl# #»# # # #á#ˆ# #fl #«#fl# # -# # # # # # # # #fl # # #fl# # # # # # (# # # - 3. N o v e l m e t h o d f o r d e t e c t i o n o f b - l a c t a m a s e s b y #«# # #fl# #fl# #, # #fl# # # # #»# # # # # # 4 -# # # # # # # #fl# # # ) # # # # # - #«# # # # # # # # # # # # # # # # # # # #fi# # # # # # # # # # # # # # # # #`#fl#»# # # # # # # # (# # # # # # #fl# # # #fi#, # # #»# # # # # #fi# # # # #, # # # # # # # # # #, # # # # # # # #fl# # # # # # #.#fi. ), # # # # # #fl # #«# # # # #fl# # # # # #`#fl#»# # #fl #»# # # # # # # # # # # # #`#fl# # # # # # # # #fl# # #»# # # # # # # # # # # # # #fl - #`#fl# # # # # # # #«# # # # # # # # #«# # # # #fl# # # # #fi# # # # # #fl# # # # #»# # # # #»# # # # # # # # # # #. fi. 2 0 %#fi# #»# # # #fl# # # # # #fl# # #`# # # #fl# # #fl# # # # # # #»# # # #fl# #fi# #`# #»# # # # # # # # # # # # # # #`#fl#»# # # # # # # #«# # # #fl# # # # # # # # # #fl# # # # #, # # # # # #fi# # # # # # # # #fl# # # # #» #«# # # #fl# # # # # # # # # # # # # # #fl# # - # # # # " ", # 1, 9-3, 2 # # # #. fl : 1. S a w a i, T. M e c h a n i s m s o f b a c t e r i a l r e s i s t a n c e t o u s i n g a c h r o m o g e n i c c e p h a l o s p o r i n s u b s t r a t e / H. C. C a l - l a g h a n [ e t a l. ] / / A n t i m i c r o b i a l a g e n t s a n d c h e m o t h e r a p y. 1 9 7 2. V o l.% 1, #ª 4. P.% 2 8 3-2 8 8. I ' ƒ ' 2-0A;RF <.-., /FR5;RFD -.-., <D5c/RF /.0., 2@/RF *.@., *1*2RF -.@. #" «" # # #fl#«#»# # # # # #»# #fi# # #»# # #fl# # # # # # #fi#fl# # " # # # #«# # # # # #fi# # # #fl#fi# # # # #»# # # # # # # #fl# #»# # #fl#»». ##»# # # #`# # # #»# # #«# # # #fl# # # # #«#fl# # # - # # # # # # # #fl # # #«# # # #»# # # # # #`#fl#»# # # # # # # #fl# # # # # # # # # # # # # # # # # # # # # #«# # # # # # # # # # # # #«# # # # # # #«#fl# # -# # # # # - #»# # # # # # # # # #. [ 3 ]. # # # # #fl# # #fl# # # # # # # #»# # #ˆ# # # # # #«# #fl# # # #«# # # # # # #»# # #fl " # #fl# # #á # # # # #ˆ#fl# # #, # #»# # # #fl# # # # # #fi#fl# #fl# # #fl# # # #»# # # #. " #`# # # #fl# #»#, #`# # # #»# # # # # # # #fl# # # # # # # # # # # # # #»# # # # - #fl#fi# # # # # # # # # # # #»# # # #`# # # #»# # # # # # # # # # # # # # # # # # # #á#ˆ#fl# # #fl# # #»# #fl# # # # #»# # #«# # # #fl# # # # #fi# # # # # # # # # #»#»# # #«#fl# # -# # # # # # # # # # # # # #«# # # # # # #, # # # # # #fl # # # # # - # # # # #«# # # #fl# # # # # # # # # # #fl# # # # # # # # # # # #fl# #»# # # # # #fi#fl# # # # # # # # # # # # # #`# #fl# # # # #fl# # # # # # # # # # # # # # # # # # #«# # # # # # # #«# # # # # #«# #fl# #fl# # # # #»# # #»# #«# # #»# # # # # #fi# # # # # # # # # #«#fl -# #fl#»# -#»# #»# #fl# # «" # # " # # # # #». ## # # # # # # # # #fl#»# -#»# #»# #fl# # # # -# # # # # # # # # # #fl# # #fl# # #, #»# # #»# #«# # #fl # # #fi# # # # # # # # # # # # # # # # # #fl# # # # # #`#fl#»# # #fl# # # # # #fl# # # # # # # # # # #fl# # «#»# # # # # - # # #fi# # # # # # #`#fl#»# # #á # #fl# # # #fi# # #á #»# # # # # #«#fl# # -# # # # # # # # # # # #» #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # #«# # # # # # #`#fl#»# # # # # # # #«# # # # # # # [ 1, 2 ]. " # # # # #fl# # #fl # # # # # # # # #fi# # # # # #«#fl# # # # #fi# # #»# # - #, # # # # # #fl # #«# # # # # # #`#fl#»# # # #»# #«#»# # # # # #, # # # # # # # # # # #«# # #fl# # #fl# # # # # # # # #«# # # #fl# # # # # # # # #fl# # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # #`# # # # # # # # # # # (# #»# # #»# #«# # #»# # # # #fi# # # # # # # # # # # # #á#`#fl# # #fl # # # # #«# # # # # # #`# #»# # # #»# #, # # # # # # # #fl ), #«#fl# # # #fi#fl# #fl# # # #`# #»# # # # # # # # # # # #«#fl# # -# # # # # # # # # # # # #fi# # #fl# # # # # #»# # # #fl # # # # #fl# # # # # # # #«# #fi# # #fl# # # # #«# # #fl# # # # # # # #fi# # # # # # #«# # # # # # #`#fl#»# # # # # # # # #«# # # #fl# # # # # # # # # #fl# # # # #, # # # # # # # # # # #fl# # #fl# # # # # # # #fl# # # # #. 79

fl # # #»# # # #ˆ#fl# # # #»#»# #fl#fi# # # # # # # # #fl# # # # #«#fl -# # # # # # # # #»# # # #`#fl# # # # # : # # # # # # # # #fl# # # # # # #fl# # # # # # # -# # # # # # # # # # #á # # # # # # # #»# # # # # # # # # #fl # # # # #fl# # # # #» # # # # # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # # # # # #» # # #fl# # # # # # # # #» # #fl# # #á # # # # #fl# # # # # # # # #«# # # #fl# # # # # # # # # # # # # # # # # # # #`#fl# # # # # # # #«# # # # # # # # #fl# #fl# # # #»# #»# # # # # # #fl# # # # #. 0, 3 2 2 (# = 0, 0 0 2 ), # #» # # # # # # # # # # # #`#fl# # # # # # # #«# # # # # # # fl fl fi. " #«# # # # # # # # # # # # #«# # # # #fl# #fl# # # #«#fl# # -# # # # # # # # # # # # #fi# 0, 2 8 6 (# = 0, 0 0 6 ). " # # #fl#fl # # # # #`#fl# # # # # # # #«# # #«# # # # # #»# # # # # # 1 2 4 # # # # #fl# # # # # # # #, # #fi# # # # # # # #fi# # # # # #fl #«# # # # # # # # #fl# # # # # # #fl # # # - #» # # #fl# # # # # #fl#. # # # #fi# # # # # #fl# # # # #fi# # # # # #»# # # # # # # # # # #fl # # # # #fl# # # # # # # # # # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # #«# # # # # # # # # # # # # # # # # # # #, # #fi# # # # #fl# #fl# # # #fl # # - # # # # # # # #» #`# #»# # # # # # #fl# #»# #fl# # # # # #«# # # #fl# # # # # # # # # # #`# #fl # # #fl# # # # # # # # " " " ( 2 6 #»# # #`# #fl# ). 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" # #fl#fi# # # #»# # # # # #»# # # # # # # # # # # #«# # # # # # #, #fl# # # # # # # # #»# # # # # # # / # # # # # # # # # #, # # # # #`#fl#»# # #fl # # #fl - # # # #á#`#fl# # # # # # #»#»# #fl#fi# # # # # #fl, #»# #»# # # # # 1 4, 8 #»# # # # ( 9# # # # # # # 5 % # #fl# #fl# # #, # #fl # # # # #»# #ˆ# # #»# # #«#fl# # -# # # # # # # # # # " " : 1 2, 4 1 7, 3 ). # # #fi#, # #»# # # # # # # # # # #»# # #fl# # # # # # #»# # # # # #fi# # #»# # # # # # #. " # #«# # # # # # # # # # # #«# # #«# # # # # #»# # # # # # # # # # # # " # # # # #fl# #»# # #fl# # #, # #»# # # # # #»# #fl# # # # #fl# #»# # #fl# - #»# # # # # # # # #»# # # # 2 0 ". " # #fl#fi# # # # # #fl# # # # # # # # # # # #fi# -#fi#fl# # # #, #»# # # # #»# # # # # # # # #, # # #»# # # # # # # # #fl# # #«#fl# # - # # #»# #»# # # #fi# # # # # #fl #«# # # #fl# # # # # # # #`#fl#»# # #fl # #»#»# #fl#fi# # # # # #fl # # # # # # # # # # # # # # # # # # #»# # # # # # # # # # # # # # #fl# # # # #» # # # # # # # # # #«# # #fl #«# # # #fl# # # # # # # #`#fl#»# # # # # #«# # # # # # # # #«# # # #fl# # # # # # # # # # # # #fl# # # # # # #fi# # # # #fl# # # # # # # # #fl# " " " " ". " #»#fl # # #fi#fl# #fl# # # #fl # # # # # # # # # # # # # # # # # # # # # # #»# # # # #fl# #»# # # #fl# #»# # # #fl# # # # # # # #fl# # # # # # #»# # # # # # # #fi# - #«# # # # # # # #fl#»# # # # # # # # # # # # #fl#fi# #fl# # #»# # # #`# # # #»# # # # # -# # # # # # # # # # # # #fl# # # # # # # # #«# # # #fl# # # # # # # # # #fl# # # # # # # # # # # # # #, # #fl# # # # # #»# # # # # # # # #»# # # # # # # / # # # # # # # # # - #» # # # # #fl# #fl# # #fl# #«#fl# # -# # # # # # # # # # # #fl# # # # # # # # #fl# # # # # #. " # # # # # # # #«# # # #»# # # # # # # # # #fi# #»# # -#fi# # # # # # # # # # # # # # # #, # # # # # #fl #«# # #fl#fl #`# #»# # # # # # # # # #fl# # #á # #fl# #«# # #fi# - # #fl# # #fi [ 4 ]. " #fl# # #»# #fl#fi#»# # #fl# # # # #fl# #fl#fi # # #»# #fl# # # #fl# # # # # #»#fl # # #»# # # # # # # #`#fl# # # # # # # #«# # # # # # # # #fl# #fl# # #, # # # #á#`# # # # # #«# # # # # # # # #«# # # # #fi# # # # #fl# #fl# # # # # # # # # # # #fl# # ; #«#fl# # -# # # # # # # # #fl # # #fl# # # # # #, # #»# # # #`# # # #fl # #«# # # # # # - # # # #«# # # # #» # #«# # # # # # # # # # # # # # 1 ) # # #fi#fl# # # # # # # #»# #»# # # #«#fl# # -# # # # # # # # (# # # #«# # #fl# #fl# #, # #fl# # # # #»# # # # # # # # # # # # # # # # # # # # # # # # # #fl # # #fl#`#fl# # #fl 3 0 # # # # # # # # 3 7 4 " -# # # # # # # #fl# # #, # # # # #«# # # # -# # #ˆ# #ˆ#fl# # # #fl # # #fl# # # # # # ), #» # #fl# # #á #fi#fl# # # # #fl# # # # # # # # # # # # # # # # # #`# # # # # # # # - # # # # # #fl # # # # #«# # # # # # # #fl# #fl# # #, # #fl # # # # #»# #ˆ# #fl#»# # # # # # - # # # # # # # # # #fl# #fl# # #fi# # # #»# #fi#fl# # # # # # # # # # #»# # # # ; # #fl 2 ) #«#fl# # -# # # # # # # #. " # #fl# # #á # # # # #«# #fl# # # # # # # # #`#fl# # # # # # #fl# #»# # # # # #»# # # # # # # # # #»# # # # # # # #fl# #»#fl # # #fl#`#fl# # #fl #fi# # # # # 5 # #fl# #fi#fl# # # # # # # # #«# # # # #fl#fi# # # # # # # # # # # # # # # # # # # # #fi# # # # # # # # # #fl# #fl# #fl# # # # # # # #»# #fi#fl# # # # # # #, # 3 )# # # # # # # # # # # # # -# # #«# # # # # # # # # #fi# # # # #. # #fl# # # # # # # # # # # # # # #»# # # # 1 2. 0 0 0 # #«/# # # # # #fl#`#fl# # #fl 5 " # #fl# # # # # # # #fl # # # # # # # #»#, #`# # # # # #`# # #fl# # # # # ( 7 3, 2 % ) # # # # #. " # # # # # #`# # # # # #fl# # # # # # # # # # # # # # # # # #fi#fl# # # #»# #`# #»# # # # # # # # # # # #fl# # # # # #«# # # # # # #`#fl# # # # # # # #fi# # # #fi#fl# # - # # # # # # #`# # # # # #fi# #»# #fi# #, # # # # # # # # #»# # # # # # # # # #»# # #fl# #»# # # # # # # #fl# #fi# # # # # # # # # # # # # # : #fi# # # # #fl# # # # # #»#»# #fl#fi# # # # # # #, # # # # # # # #fl #`# #»# # # # # # # # # 1 ) "é# # # # # 1 # # # # # # #fl# # # # #fl# #»# # # #»# # # # #«#fl# # -# # # - (# #»# #fi# # ) # # # # # # # # # # # # #»#. " #»# # #`# #fl, #fl#»# # # #«# #fl# # # # # # # # # # # # - # # # # # # # #»# # #á # # # # # # #, #»# #fl#fi# # # # # # # # #»# # # # # # #`# # # # # # #fi# #»# #fi# # #«# # #»# # # # # # # # #, # # # # #«# # # # #«# # # # # #, #»# #fl#fi# #fl# # # # #fi# # # # # #fl# # # # #»# # #á # # #»# # # # # # - #fi# #«# # # # # # #»# 0, 5 # # #»# #fl# # # # # # # # # # # # # # # # # #`#fl#»# # # # # # # # # # # # # # # # #fi# #`# # # # # #fl# # # #fi#, # # # # # # # #fl # # #»# # # # # # #»# # # # # # # # # # #fi# # # # # # #. ( R = 0, 9 5 ) #`# #»# # # # # # # # # # #`#fl# # # # # # # #«# # # # # # # # #fl# #fl# # #, " # #fl# # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # # # # # # # # #á#`# # # # # #«#fl# # -# # # # # # # # #fl # # #fl# # # # # #, # # # # # # # # - # # # # # #fi# # # # #»# # # # # # # # #fl#»# -#»# #»# #fl# # «" # # " # # # # #» #«# # # # # # # # #fi# # # # # # # # # # # # # # # # #`#fl#»# # # # # # # # ; (" " " «" " " # # # #», " #fl#»# # #«# # # # " #fl# # # # #»# ). 2 ) "é# # # # # 2 # # # # #`# #fl# #»# #»# #fl#fi# # # # # # # # #»# # # fl fifl fl. " # #fl#fi# # # # # # # #fl# # # # # # #fl# # # #, #«# # # # # # #fi# # # #fl# # # # #»# # #á # # #»# # # # # # # # # # #, # # # # # #fl# # # # # # # # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # - # # #»# # # # # # # #»# # # # # # # # # # # # # #fl# # # # # # # #fi# # # # # # #`# - # # # # # #»# #»# # # # # 1 3, 0 % ( 9 5 % " " : 1 0, 5 1 5, 5 ), # #fl#fi# # # # # #fl# # # # # # # # #fi# # # # # #fl# # # # #»# # #á # # # # # # #fi# #`# # # # # #fl# # # #fi#, # # # # # # # # # # # # # #»# # 7, 3 % ( 9 5 % " " : 5, 7 9, 4 ). "ó# # # # # # - # # # # # # # # # # # #fl#`# # #»# #»# #fl#fi# # # # # # # #fl# # #«#fl# # -# # # - # # # # # # # # # # # # #fl# # # # # # # # #fl# # # # # # # # # #»# # #«# # # # # #fl# # # # # # # # # # # # # # # # #»# # # # # # # # #, # # # # # #«# # # #fl# # # # # # # #fl 0, # # # #»# # # # # # # # 8 3, 4 %. # # #fl# # # # # # # #fl# #fl# # # # #«# # # # # # # # # # # # # # # #»# # #fl#fi# # ; " # # # #fl# # # # # # # # # # # # # # # # # # # # # #, #`# # # # # # #fl# # 3 ) "é# # # # # 3 # # # # # # #fl# # # # #fl# #»# # # # # # # #«#fl# # -# # # - #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # # # # # # # # # # # # # # #fl - # # # # # # # # # # # # # # # #»# # #á # # # # # # #, # # # # # # # # # # # # #»# # # # # # # #fl# #» # # # #fi# # # # # #fl# # # # #»# # #á # # # # # # #fi# #`# # # # # #fl# # - # # # # #fl# # # #, # # # # # #fl # #fl#«# # # # # # # # # #fi# # # # # #fl# # # # #»# # #á # #fi# ( R = 0, 1 7 7, # = 0, 0 2 4 ) ; #fi# # # # # # # # # #fl# # # # # # # # # #fl# #»# # # #»# # # # # # # # # # # # # # # # # # #fi# #`# # # # # #fl# # # #fi# ; # # # # #«# # - #»# # #«# #, # #fi# # # # # # # # # # #fl# # # # #fl#fi#fl# #fl# # # #á # #fl# #fi#fl# # # #á.# # # # # #fl# #fl# # # # # # # #«# # # # # # # #fl # # # # # #`# # # #»#. " # # # # # # #fl#fi#fl# # # # # # # #fl# # # # # # # # # # # # # # # # # # #fl# #fi# fi. # # # # # #fl# #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # # # # # # # # # 1. " # 8 9 % ( 9 5 % " " : 8 4, 2 9 3, 8 ) # # # #«# # # # # # # # # # # # # # # # # # #`#fl# # # # # # # #«# # # # # # # # #fl# #fl# # # # # # # # -# #«# # #fi# #fl# #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # #á, # # # # #`# # # #fl# # # # #» # # #fl# # # # # # # # ( n = 9 1 ) #fi# # # # #fl # # # # #»# # # #»# # # # # # # # ; 80

2. " # # # #»# # #fl# # # # # # #»# # # # (#«# # #fl#fl 2 0 % ) #«#fl# # -# # # # # " # # - # # # # / / "ó#fl#fi# # # # #»# # #fl # # # # #»# # 2 0 0 4. #ª 2 # # # # # # # # # # # # # #»# # # # # # # # # #fi# #»# # # #fl# # # # # #fl# # #`# # # #fl# ".% 7-1 2. # #fl# # # # # # #»# # # #fl# #fi# #`# #»# # # # # # # # # # # # # # #`#fl#»# # # # # # # - 2. P é r e z - L l a r e n a, F. J. B e t a - l a c t a m a s e i n h i b i t o r s : t h e #«# # # # # # # #fl# # # # # #«# # # #fl# # # # # # # # # # # # # #fl# # # #«# # # # # # s t o r y s o f a r / F. J.% P é r e z - L l a r e n a, G.% B o u / / C u r r. M e d. # # #fl# # # # # 2, 0-3, 1 # # # # ; C h e m. 2 0 0 9. V o l. 1 6, #ª 2 8. P. 3 7 4 0-3 7 6 5. 3. " #fl#»# -#»# #»# #fl# # «" # # " # # # # #» # # # # # # # #fl# # # #fl# # - 3. A b e y l a t h, S. C. D r u g d e l i v e r y a p p r o a c h e s t o # # # # # # # # #`# #fl # # # # # #fl# # #«#fl# # -# # # # # # # # # # # # # # # # # # #»# # o v e r c o m e b a c t e r i a l r e s i s t a n c e t o b e t a - l a c t a m a n t i b i o t i c s # # # # # # # #«#fl# # #«# # # # #fl# # # # # # # # # # # # # #fi#fl# #fl# # # # # # #fl#fl / S. C. A b e y l a t h, E. T u r o s / / E x p e r t. O p i n. D r u g. D e l i v. #`# #»# # # # # # # # # # # # # # #«# #fi# # #fl# # # # #«# # #fl# # # # #. 2 0 0 8. V o l. 5, #ª 9. P. 9 3 1-9 4 9. 4. " #fl# #fl#fi# # #, "é.". " #»# #«#fl# # # #»# # # # # #fl#fi#fl# #fl# # # fl. #`# # #»# # # # #fl# # # # #»# # # # # # # # # # # # # # # # # #fi# #»# # -#fi# # # # - 1. " #fl# #fl# # #, "."ó. "ó# # # # #«# # # # # # #`#fl#»# # #fl # #«# # # # -# # # # # # # # #fl# # #fi# # / "é.". " #fl# #fl#fi# # #, ".#. C# #fl# #á# / / # # #`#fl#»# # #fl # #»# #fl# # # # #fl# # #»# #fl# # # # #»# # # # # # # # # # # # #«# # # " # # # # #`#fl#»# # # "ó# # # # #«# # # # # # # # " # # # # # # # # #«# # # # # - # # #fl# # # # # # # / "."ó." #fl# #fl# # #, "."." # # # # # #`#fl# # #, "." # # # # #fl# # # # #.. 2 0 0 1. " # # 3, #ª 4. ".% 3 4 8-3 5 4. ˇ ˇ ƒ ' >DV-2D @.*. #" «" # # #fl#«#»# # # # # #»# #fi# # #»# # #fl# # # # # # #fi#fl# # #fi# # # #«# # # # # #fi# # # #fl#fi# # # # #»# # # # # # # #fl# #»# # #fl#»». "ó#fl# # #«# # # #`#fl#»# # # #»# # #fi# # # # # #fl#fi - fl»» flfi : # # # # # # # #`# #»# # # # # #»# # #fl#`# - #»# # # # # #fl# #»# #«# # #»# # # # # # # # # # # # #fl# #», # # # # # # # # # # #á#`# #fl# #fl# # #»# # # # # # # #fl# # # # # # #fl# # #fi# # # # # #«# #fl# # (# # # # # #fl# # #fl # #»#fl#«## #fl# # #»# #fl# # # # #»# # # # # #»# # # # # #»# #»# # # #fl# # # # # # # #fl # # # - #fl# # # # # # #»# # # # # #á# # # #fl # # # # # # #fl# # #fl # # # # #fl# # # # # - # # # # # # #»# # #á # # # # #fl# # #fi# # # # # # #fl# # # #»# # # # #fl# # #fl# # # # " " 2 # # #ˆ# # ) # #«# # # # # # #» # # # # # # # # # # # # # # # #«# # #fl# # # # # # # # # # # ; #fi# #»# # # # # # # # #fl# #fi#fl# # #á #» # # # #fl# # # # # # # # #fl# # #fi#fl# # #fl#, # # # # # # #«# # # # # # #» # # # # # # # # # #«# # #fl# # # # # # # #» # # # #fl - # # # # # #fl# # #fl# # # # # # # # # # #fl#»# #fl# # # #, #»# # # #fl# # #fl# # # # # # # # # # # # # #fl# # #«# # # #`#fl#»# # # # #»# # #fi# # # #. # # # #fl#»# #fl# # # # # # # # # # # # #fl# # # # # # #»# # # # # # # # # # #»# # ; fl fl fi. " #«#»# #fl#fi# # # # # 6 0 # # # # #fl# # # # #»# # # # # # #»# # # # # # # #«# # #«# # # # # # # # #á # # # # # # #fl# # #fl # # # # # - #» # # #»# # # # # #fl# # # # # # # # #«# # #fl# # # # # # # # # # # # # # # # # #»# #fl # #fl # # # # # # # # # # # # # # # #«# # # # # # # # # # # # # # # # # # # # # # # # #fl# # # # ; 5 # #fl# #fi# 6 9 # #fl#. " # # # # #» # #»# # # # # # # 2 5 #`#fl# # # #fl# # # # #fl# # # # # # # #á # # # #fl# # #fl# # # #á (" "é ) ; # #fl# #fl# # # # # # # # # # # #fl (# # # # # # # # # # # #»# # # # # # 1 2 #`#fl# # # #fl# ; # # #»#»# #fi# # # # # # # # # # # #fl# # #fl (# # #fi#fl# #» # # #»#»# # #fl# # # # # #fl 2 5 # # 2 )/# [ 1 ]. " # - # 1 2, # # # # # # #fi#fl# # # #`#fl#»# # # # 1 ; # # # # #`# #»# #fl, #» # #fl# # #fl - # # # # # # # # # # # # #fl# #»# # # # # # #fl# # #fl # # # # # # #fl# # # # # #fl# # #«# - # # # # # -# #fl# #fl#fi# # # # # #á#ˆ# # # #fl#`#fl# # #fl# 1 0 # # # # #fl# # # #, # # #`#fl#»# # # # #»# # #fi# # # # # # #fi#fl# # # # # # # # # #`#fl#»# # # #«# # # # # # #», # #»# # # # # # #`#fl#»# # # # # # # # # # # # #fl# 9 # # # # #fl# # # # ) ; #» # # #`# #»# # # #»# #, # # # # # # #fi# # # # # #»# # # # # #»# # #fl# # #fl# #fl# # # # # # #fl# #fi# # # # # # # #fl# # #fl# 5 # # # # #fl# # # # (# # # # #fl# #»# # # # # # # # # # #fl# # # # # # # # # #fl# # # # # # #fl# # #fi# # # # # #«# #fl# # : # # # # # #fl# - # # # # # 1 # # # # #fl# #, #»# #«# # # # # # # # # 2, # # # # # # # # # 1, # # # # # # # #fl# # # # # # # #ˆ# # # # # # # # #fl# # #fl # # # #fl# # # # # # #»# # # # #`# # # # # # 2 ) ; #» # # # # # #fl# # #fi# # # # # # # # # #fl# # # 2 #`#fl - # # #á# # # #fl # # # # # #fl#fi#fi# # #«#fl# # #`#fl#»# # # #»# #»# # # # # #. # # # #fl# #, #» # # # #»# # # # # # #»# # # # # # # #fl# 9 # # # # #fl# # # #, " # #»# #fl#fi# # #fl # #»#»# #fl#fi# # # # # # # # # # # # # #á# # # # #, #`# # #«# # # #fl#`# # # #»# # #fl# # #fi#fl# # # #fl# 1 1, #»# # #fl# # -# # # # # # #`#fl#»# # # # # # #fl# # # # # #fl# # #`#fl#»# # #fl #»# #»# # # # # # #»# # #»# #«#»# # # #á# # # # -# # # #fl# # # 3, # # #fi# # # # -# # #fi# # # #fl# # # # # # #»# # # #fl# # # 2, # # # # #á # # # # # # # # # # # # # # # # # # # # # [ 2 ]. " # #fl#á# #»# # # -# #fl# # # # #fi#fl# # # #fl# # # #fi# # #fl# # # # #fi# # # 2 # # # # #fl# # #, # #á# # - # # #«#fl# # # #fl #fi# # # # #fl # #`# #»# # # #fl # # # # # #fl# # # # # # # # #fl# # # # #fi# # # # #fl# # # #«# # # # # 1# # # # #fl# #. " #«#»# #fl#fi# # # # # #fl # # # - # # # #fl# # #fi# # # # # #«# #fl# # # #«# # # # # # #» # # # #»# # # # # # #»# # # # # #fi# # # #» # # # # #fl# #fl# # #fl# # # #á# # # # # # # #fl# # # # # # # # # #fl#»# # : # # # # #fl#. " # # # # #fl# # # # # # # # #fi# # # # # # 4 7 % #«# # # # # # # # # #fl#fi#fl# #fl# # #fl # # # # # # # # #á# # # # # # # # # # # # # # # # # # # # # " " " # #fl# # #»# # # # # # # # # #»# # # # # # #fl# # #fl # # # #fl# # # # # # #»# # # # # # # #ˆ# # # #`#fl# #fl# 2 #`# #»# # # #»# #fl #fl#fi#. " # # # # # #fl# # # #fl# # # # # # # #á# # # #fl # # 2 6 % - #fi# # #«#fl# 2 -# # # # # # [ 4, 5 ]. " # #fl#á# #»# # #»# # #`#fl# # # # - # #fl# # # # # # # # # # #»# # # # # # # # # # #»# # # # # #fl# # # # #«#ˆ#fl# # # # # # # # # #fl# # # # # # # #fl# # #fi# # # # # #«# #fl# # # #«# # # # # # # # # # # # # #fl# #fl# # # # #fl# # #fi# # # # # #«# #fl# #, # #fl# # # #fl# #fi# # # # # # # #»# #»# # #fl# # #fi#fl# # # #fl# # #»# # #fl# # # # # # # # #`#fl#»# # # # # # # #fl# [ 3 ]." " "í (# # #«#. 1 ). :DE0-;D 1. grnd,dviol 8GOIFRH2RGR REPI2D : (]TLVITLL, TINRPI2HRFD22@I Lc; 1 9 9 9G. ) " # # # #fl# # # # # # # # # #á# # # # # # # # # # # # # - # # # # # # # # " # # # # # # # # #`#fl# #fl# 2 #`# #»# # # #»# #fl # # # #fl# # p e r o s 7 5 # # # #á# # # # " # # # # #fl# # # # # # # # #fl# # # # # - # # #ˆ# # " # # # # #fl# # #fl # # # #fl# # # # # # #»# # # # # #á# # # #fl " " 2 # # # #!S 5, 6 # # # # # /#, # #!S 6, 1 # # # # # /#!S 6, 1 # # # # # /# < 6, 1 # # # # # /# < 7, 8 # # # # # /#!S 7, 8 # # # # # /#, # # < 1 1, 1!S 1 1, 1 # # # # # /# # # # # # /# 81