Folia Pharmacol. Jpn. 140 TRP TRP TRPV TRPA TRPV thermo-trp Na TRP transient receptor potential TRPC TRPV TRPA TRPM TRPP TRPML TRP thermo-trp TRPV TRPA TRPM Thermo-TRP thermo-trp thermo-trp 1. Thermo-TRP 1 TRPV1 TRPV TRPV C A thermo-trp TRPV - - E-mail: tatsuya-kamei@ds-pharma.co.jp Title: Novel therapeutic approach to neuropathic pain: Hot and Cool TRP-channel family Author: Tatsuya Kamei, Masanori Miyauchi, Yoshihiro Oyamada, Isao Shimizu
thermo-trp TRPV KO TRPV TRPV TRPV A-Abbott Laboratories SNL: spinal nerve ligation BCTC JNJ- Johnson & Johnson mg/kg flinching TRPV TRPV UV-B, TRPV AMG-AmgenAMG- TRPV ABT-Abbott KO TRPV TRPV TRPV TRPV TRPV PHE 2 TRPA1 TRPA TRPV TRPV thermo-trp TRPA TRPA SB- GlaxoSmithKline AZD- AstraZeneca MK- Merck/Neurogen GRC- Lilly/Glenmark Pharmaceuticals JTS- Japan Tobacco AMG- Amgen b PHE- PharmEste b ABT- Abbott Laboratories DWP- Daewoong Pharm
A-Abbott Laboratories CCI: chronic constriction injury HC- SNI: spared nerve injury SNL HC- CHEM Chembridge Corporation STZ TRPA TRPA TRPA TRPA GRC- Glenmark Pharmaceuticals CB -Cubist Pharmaceuticals/Hydra Biosciences GRC-, TRP CCI 3 TRPV3 TRPV thermo-trp KO TRPV TRPV Hydra Biosciences Glenmark Pharmaceuticals TRPV GRC- CFA: complete Freund adjuvant CCI TRPV SAR /GRC- Sanofi/Glenmark Pharmaceuticals CCI TRPV 2. Thermo-TRP Thermo-TRP TRPV 1 TRPV1 TRPV TRPA GRC- CB- HC- CHEM AP- A- SAR /GRC- Glenmark Pharmaceuticals Cubist Pharmaceuticals/ Hydre Biosciences Hydra Biosciences Chembridge Corp Scripps Inst Abbott Laboratories Sanofi/Glenmark Pharmaceuticals TRP CCI ED mg/kg SNL SNI STZ CFA CCI TRPV CCI
thermo-trp TRPV Ca TRPV Ca TRPV C, TPRV 2 TRPV1 TRPV 1 OTC NGX- NeurogesX/Astellas Pharma NPRS PGP. NGX- EU EU HIV NGX-, civamide Winston laboratories 2 resiniferatoxin: RTX RTX TRPV RTX TRPV RTX i.t. TRPV RTX TRPV DRG C NGX-/Qutenza NGX- ALGRX-/Adlea Civamide/Zuacta cis-capsaicin Resiniferatoxin NeurogesX/ Astellas Pharma HIV NeurogesX Anesiva... Winston Laboratories NIH /
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